Retrovirology
Volume 1
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 HypothesisPre-exposure chemoprophylaxis for HIV: It is timeStephen M Smith  Saint Michael's Medical Center and The New Jersey Medical School, Newark New Jersey 07102, USA  author email corresponding author email
Retrovirology 2004,
1:16doi:10.1186/1742-4690-1-16 Abstract
The HIV-1 plague continues unabatedly across sub-Saharan Africa. In Botswana and Swaziland, nearly 40% of the entire adult population is already infected. No current program is capable of slowing the advancing tide. An effective vaccine and widespread treatment are years, if not, decades away. In this most urgent situation, I propose that pre-exposure chemoprophylaxis be studied as a means to reduce the spread of HIV-1 among at-risk individuals. | 
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