Table 1

Examples of cellular factors inhibiting early steps of retroviral cycle.

Restricted Retroviruses^a

Step being affected^b

Viral determinant^c

Distribution

Cloned

CEM15

HIV-1

RT

Vif

human

yes

Fv1

N-MLV or B-MLV

between RT and integration

CA

Mouse

yes

Ref1

N-MLV, EIAV

between entry and RT

CA

various mammals

yes*

Lv1

N-MLV, HIV-1, HIV-2, SIVmac, EIAV

between entry and RT

CA

various mammals

yes

Lv2

HIV-2

between RT and nuclear entry

CA / Env

human

no

Abbreviations: ^a HIV-1, human immunodeficiency virus type 1 ; HIV-2, human immunodeficiency virus type 2 ; SIVmac, simian immunodeficiency virus macaques ; N-MLV, N-tropic murine leukemia virus ; B-MLV, B-tropic murine leukemia virus ; EIAV, equine infectious anemia virus. ^b RT, reverse-transcription. ^c CA, capsid protein ; Env, envelope glycoproteins. *Personal communications and unpublished data.

Nisole and Saïb Retrovirology 2004 1:9   doi:10.1186/1742-4690-1-9