Table 1

Summary of the radial diffusion assay results comparing host defense peptides with a clinically used antibiotic (Ampicillin)

M E C (μg/ ml)

Organisms

Protegrin-1

LL–37

HBD 2

Plectasin

Novi- G10

Ampicillin

S. aureus

0,91 ± 0,04

4,74 ± 0,1

9,13 ± 0,5

2,42 ± 0,4

4,2 ± 0,4

10,50 ± 0,2

S. epidermidis

4,48 ± 0,2

13,09 ± 0,6

8,96 ± 0,2

8,20 ± 0,5

2,8 ± 0,02

ND

E. faecalis

4,46 ± 0,3

13,61 ± 0,7

-

10,60 ± 0,7

4,3 ± 0,3

28,85 ± 0,6

P. aeruginosa

3,3 ± 1,1

12, 28 ± 0,5

6,87 ± 0,8

> 128

1,56 ± 0,4

ND

E. coli

2 ± 0,1

11,66 ± 1,5

3,66 ± 0,3

79,10 ± 0,3

1,63 ± 0,3

18,9 ± 0,9

A. baumanii

5,01 ± 0,2

13,13 ± 0,2

3,19 ± 0,5

> 128

4,5 ± 0,02

ND

All clinical isolates from human wounds showed significant sensitivity to HDPs. ND: not determined. MEC: minimal effectory concentration. MEC > 128 means that the tested bacteria is not susceptible to the drug tested. Depicted data consists of 3 individual experiments; each condition was performed in quadruplicates

Steinstraesser et al. Retrovirology 2005 2:2   doi:10.1186/1742-4690-2-2