Retrovirology
Volume 2
|
Viewing options:Associated material:Related literature:- Articles citing this article
- Other articles by authors
- Related articles/pages
Tools:Post to:
|
 CommentaryHIV-1 Tat, apoptosis and the mitochondria: a tubulin link?Mauro Giacca  Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy  author email corresponding author email
Retrovirology 2005,
2:7doi:10.1186/1742-4690-2-7
|
|
| Published: |
7 February 2005 |
Abstract
The Tat protein of HIV-1 is a powerful activator of viral gene expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a remarkable number of other biological activities, among which the induction of cellular apoptosis. Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis. | 
on Google Scholar
