Table 4 |
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|
Ratio of nonsynonymous (dn) to synonymous (ds) substitutions in NC and p6 sequences from six HIV-1 infected mother-infant pairs involved in vertical transmission. |
||||||||||
|
Pair |
Mothers |
Infants |
||||||||
|
|
||||||||||
|
N |
p1 |
p2 |
p3 |
dn/ds |
N |
p1 |
p2 |
p3 |
dn/ds |
|
|
|
||||||||||
|
B |
13 |
0 |
0 |
100 |
1.37 |
11 |
0 |
100 |
0 |
1.00 |
|
C |
9 |
0 |
0 |
100 |
1.51 |
15 |
11.72 |
86.09 |
2.19 |
22.84 |
|
D |
17 |
0 |
99.02 |
0.98 |
68.79 |
12 |
87.26 |
0 |
12.74 |
6.75 |
|
E |
11 |
83.68 |
0 |
16.32 |
33.75 |
12 |
48.04 |
51.02 |
0.94 |
37.57 |
|
F |
18 |
0.03 |
0 |
99.97 |
1.20 |
15 |
21.48 |
77.20 |
1.32 |
9.00 |
|
H |
16 |
0 |
100 |
0 |
89.00 |
- |
- |
- |
- |
- |
|
I1H |
- |
- |
- |
- |
- |
11 |
100 |
0 |
0 |
21.24 |
|
I2H |
- |
- |
- |
- |
- |
8 |
68.65 |
0 |
31.34 |
5.47 |
|
|
||||||||||
|
Total |
84 |
13.95 |
33.17 |
52.88 |
32.60 |
84 |
48.16 |
44.90 |
6.94 |
14.82 |
|
|
||||||||||
|
N: Number of clones sequenced, Totals were calculated as the average of all values. p1: proportion of conserved codons as a percent p2: proportion of neutral codons as a percent p3: proportion of positively selected codons as a percent; dn/ds = dn/ds ratio at p3 |
||||||||||
|
Wellensiek et al. Retrovirology 2006 3:21 doi:10.1186/1742-4690-3-21 |
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