Table 2 |
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|
Tax activated genes involved in aneuploidy |
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| Genbank Accession Number |
Gene |
Fold change |
Function |
|
|
|
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| D87898 |
Arf1 |
ADP-ribosylation factor 1 |
2.6 |
Membrane vesicle formation, inactivation nec. for mitotic Golgi breakdown, chromosome
segregation, and cytokinesis [95–97] |
| BC054097 |
Cetn3 |
centrin 3 |
2.2 |
spindle cell body duplication need for bipolarity in cytokinesis [98–103] |
| AF016583 |
Chek1 |
checkpoint kinase 1 homolog (S. pombe) |
2.3 |
needed for S and G2 checkpoints after DNA damage; Tax has been shown to disrupt its
function [24,25,104–106] |
| AF098508 |
Dctn3 |
dynactin 3 |
2.4 |
light-chain subunit of dynactin complex (p24); dynactin complex involved in vesicle
movement; dynactin complex interacts with NuMA and dynein in order to tether microtubules
at the spindle poles and that are essential for mitotic spindle pole assembly and
stabilization; recruitment by ZW10 protein to the kinetichore [107–110] |
| NM_009503 |
p97(Vcp) |
valosin containing protein |
3.0 |
aka cdc48; needed for spindle disassembly after segregation; Golgi disassembly-assembly
[111–113] |
| BC046832 |
Ppp1cb |
protein phosphatase 1, catalytic subunit, beta isoform |
2.5 |
antagonist of Aurora B kinase during mitosis, i.e. regulating the protein interface
between the centromeres and the mitotic spindle; possible downstream targets include
kinetochore protein Ndc10, CENP-A, which substitutes for histone H3 in centromeric
nucleosomes, and inner centromere protein INCENP; mutation of PP1 or inactivation
was shown to result in cytokinesis defects. [114] |
| NM_008989 |
Pura |
purine rich element binding protein A |
2.4 |
involved in DNA replication and transcription; overexpression results in G2 blockage
[115,116] |
| AJ534939 |
Smc2l1 |
SMC2 structural maintenance of chromosomes 2-like 1 (yeast) |
2.8 |
aka CAP-E protein, that is part of the condensin protein complex originally identified
in Xenopus; protein complex is needed for chromosome condensation; CAP-E has been
found to interact with DNA ligase IV (DNA double-strand break repair protein) possible
interaction important for genome stability [117–120] |
| BC009167 |
Sugt1 |
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) |
2.3 |
recent study shows that SGT1 is needed for kinetechore assembly [66,76] |
| AF077002 |
Ywhah |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
2.0 |
binds to CDC25B in a phosphorylation independent mechanism [121,122] |
| BC027100 |
Zwint-1 |
ZW10 interactor |
2.1 |
specifies the kinetochore association of ZW10 which may act as part of, or immediately
downstream of, the wait anaphase tension-sensing checkpoint [123,124] |
|
|
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|
de la Fuente et al. Retrovirology 2006 3:43 doi:10.1186/1742-4690-3-43 |
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