Retrovirology

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Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants

Patricia S Fletcher, Gregory S Wallace, Pedro MM Mesquita and Robin J Shattock*

Retrovirology 2006, 3:46 doi:10.1186/1742-4690-3-46

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Preclinical evaluation of lime juice as a topical microbicide candidate

Patricia S Fletcher, Sarah J Harman, Adrienne R Boothe, Gustavo F Doncel, Robin J Shattock Retrovirology 2008, 5:3 (11 January 2008)

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Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides

A Robert Neurath, Nathan Strick, Yun-Yao Li BMC Infectious Diseases 2006, 6:150 (16 October 2006)

The HIV-1 inhibitory activity of polymeric microbicides decreases in the presence of seminal plasma, but this can be overcome by combining the compounds with pH buffering systems.