Table 4 |
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|
Definition of mutated HIV-2RODProtease susceptibility to LPV and SQV |
||||
| IC50 [μM] |
IC50mutant/IC50ROD |
|||
|
|
||||
| HIV-2 Protease mutant |
LPV |
SQV |
LPV |
SQV |
| L90M |
12.5+/-8.1 |
554.1+/-3.9 |
0.75 |
3.70 |
| L99F |
11.1+/-3.1 |
147.2+/-5.1 |
0.67 |
0.98 |
|
|
||||
|
L90M and L99F HIV-2ROD mutated Proteases were expressed in yeast. IC50 values to LPV and SQV were defined as in Fig 2A. |
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|
M'Barek et al. Retrovirology 2006 3:58 doi:10.1186/1742-4690-3-58 |
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