Figure 8.

A model of Tax1 induced transformation. A) At least two PDZ proteins, Dlg1 and a putative protein X, should be inactivated by Tax1 for the transformation of CTLL2 cells. B) Tax1 inactivates X more efficiently in Dlg1 knockdown cells than in CTLL-2 cells, resulting in the higher transformation rate. C, D) Tax1ΔC selectively transforms CTLL2 expressing low amount of both Dlg1 and X. In this case, cells expressing low amount of X always express low amount of Dlg1.