HIV infection of non-dividing cells: a divisive problem

doi:10.1186/1742-4690-3-74

Retrovirology

Volume 3

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Review

HIV infection of non-dividing cells: a divisive problem

Ariberto Fassati

Wohl Virion Centre and MRC-UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK

author email corresponding author email

Retrovirology 2006, 3:74doi:10.1186/1742-4690-3-74


Published:	26 October 2006

Abstract

Understanding how lentiviruses can infect terminally differentiated, non-dividing cells has proven a very complex and controversial problem. It is, however, a problem worth investigating, for it is central to HIV-1 transmission and AIDS pathogenesis. Here I shall attempt to summarise what is our current understanding for HIV-1 infection of non-dividing cells. In some cases I shall also attempt to make sense of controversies in the field and advance one or two modest proposals.