Review

The cell biology of HIV-1 and other retroviruses

Eric O Freed¹ and Andrew J Mouland²

¹  Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD. 21702-1201, USA

²  HIV-1 RNA Trafficking Laboratory, Lady Davis Institute for Medical Research-Sir Mortimer B. Davis Jewish General Hospital, Departments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, H3T 1E2, Canada

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Retrovirology 2006, 3:77doi:10.1186/1742-4690-3-77

Published:	3 November 2006

Abstract

In recognition of the growing influence of cell biology in retrovirus research, we recently organized a Summer conference sponsored by the American Society for Cell Biology (ASCB) on the Cell Biology of HIV-1 and other Retroviruses (July 20–23, 2006, Emory University, Atlanta, Georgia). The meeting brought together a number of leading investigators interested in the interplay between cell biology and retrovirology with an emphasis on presentation of new and unpublished data. The conference was arranged from early to late events in the virus replication cycle, with sessions on viral fusion, entry, and transmission; post-entry restrictions to retroviral infection; nuclear import and integration; gene expression/regulation of retroviral Gag and genomic RNA; and assembly/release. In this review, we will attempt to touch briefly on some of the highlights of the conference, and will emphasize themes and trends that emerged at the meeting.

Meeting report

The conference began with a keynote address from W. Sundquist on the biochemistry of HIV-1 budding. This presentation will be described in the section on Assembly and Release of Retroviruses.