Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products
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* Corresponding author: Linda B Ludwig lbludwig@comcast.net
Retrovirology 2006, 3:80 doi:10.1186/1742-4690-3-80
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BioMed Central: 5 citations
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Research
Isabelle Clerc, Sylvain Laverdure, Cynthia Torresilla, Sébastien Landry, Sophie Borel, Amandine Vargas, Charlotte Arpin-André, Bernard Gay, Laurence Briant, Antoine Gross, Benoît Barbeau, Jean-Michel Mesnard Retrovirology 2011, 8:74 (19 September 2011) Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' LTR, which is either left unspliced or alternatively spliced. We and others have demonstrated the existence of antisense transcription initiating in the 3' LTR in human lymphotropic retroviruses, including HTLV-1, HTLV-2, and HIV-1. Such transcripts have been postulated to encode antisense proteins important for the establishment of viral infections. The antisense strand of the HIV-1 proviral DNA contains an ORF termed asp, coding for a highly hydrophobic protein. However, although anti-ASP antibodies have been described to be present in HIV-1-infected patients, its in vivo expression requires further support. The present study demonstrates that ASP is effectively expressed in infected T cells and characterize its subcellular localization.
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Research
Sabri Sanabani, Évelyn de Souza Pastena, Walter Neto, Vanessa Martinez, Ester Sabino Virology Journal 2010, 7:74 (16 April 2010) |
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Hypothesis
Linda B Ludwig Retrovirology 2008, 5:79 (11 September 2008) |
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Commentary
Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions? Man Yeung, Monsef Benkirane, Kuan-Teh Jeang Retrovirology 2007, 4:74 (15 October 2007) |
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Research
Detection, characterization and regulation of antisense transcripts in HIV-1 Sébastien Landry, Marilène Halin, Sylvain Lefort, Brigitte Audet, Catherine Vaquero, Jean-Michel Mesnard, Benoit Barbeau Retrovirology 2007, 4:71 (2 October 2007) |