Research
Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products
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* Corresponding author: Linda B Ludwig lbludwig@comcast.net
1 Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Biomedical Science and Medicine, State University of New York at Buffalo, Buffalo, New York 14203, USA
2 Department of Surgery, School of Biomedical Science and Medicine, State University of New York at Buffalo, Buffalo, New York 14203, USA
3 Division of Infectious Disease, Department of Medicine, School of Biomedical Science and Medicine, State University of New York at Buffalo, Buffalo, New York 14203, USA
4 Present address: 2519 145th Circle, Vancouver, Washington 98686, USA
Retrovirology 2006, 3:80 doi:10.1186/1742-4690-3-80
Published: 8 November 2006Additional files
Additional File 1:
Figure 1S Diagram of the HIV-1 genomic regions deleted in long term survivors with respect to the HIV antisense gene HAPs coding regions. Deletions in the nef/LTR are shown as empty (Figure 1B Long term survivors) or as cross-hatched regions (Figure 1C: comparison of nef mutations in long term survivors and progressors[60].)
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Additional File 2:
Figure 2S RT-PCR analysis of Jurkat T cells transiently transfected with a vector containing the HIV-1 LTR or controls. From U.S. patent 6,392,029, example 3.
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Additional File 3:
Figure 3S Proposed model for intrinsic RNA regulatory system for HIV transcription and translation (from U.S. patent 5,919,677).
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