The strength of the HIV-1 3' splice sites affects Rev function
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* Corresponding author: Heiner Schaal schaal@uni-duesseldorf.de
Retrovirology 2006, 3:89 doi:10.1186/1742-4690-3-89
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Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy Raymond Wong, Ahalya Balachandran, Annie YQ Mao, Wendy Dobson, Scott Gray-Owen, Alan Cochrane Retrovirology 2011, 8:47 (17 June 2011) Despite their high homology, increasing individual CLK expression had distinct effects on HIV-1, CLK1 enhancing Gag production while CLK2 inhibited the virus. Parallel studies on the anti-HIV-1 activity of CLK inhibitors revealed a similar discrepant effect on HIV-1 expression. TG003, an inhibitor of CLK1, 2 and 4, had no effect on viral Gag synthesis while chlorhexidine, a CLK2, 3 and 4 inhibitor, blocked virus production. Chorhexidine treatment altered viral RNA processing, decreasing levels of unspliced and single spliced viral RNAs, and reduced Rev accumulation. Subsequent experiments in the context of HIV-1 replication in PBMCs confirmed the capacity of chlorhexidine to suppress virus replication.
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Research
Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences Nobubelo K Ngandu, Konrad Scheffler, Penny Moore, Zenda Woodman, Darren Martin, Cathal Seoighe Virology Journal 2008, 5:160 (23 December 2008) |