Table 1 |
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|
Inhibition of HIV-1 and HIV-2 Env-mediated fusion. AMD3100 or Leu3A were added to cocultures of HIV-expressing cells and target cells at the time of co-culture and fusion was measured as described in Methods. IC50 values were derived from dose-response by fitting the data to a hyperbolic decay function. |
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| IC50 (μg/ml) for fusion at 37°C |
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|
|
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| AMD3100 |
Leu3A |
|
|
|
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| HIV-1IIIB |
0.53 ± 0.07 |
0.3 ± 0.1 |
| HIV-2ROD |
>10 |
0.03 ± 0.02 |
| HIV-2SBL |
0.14 ± 0.02 |
0.09 ± 0.01 |
|
|
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|
Gallo et al. Retrovirology 2006 3:90 doi:10.1186/1742-4690-3-90 |
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