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This article is part of the supplement: 2006 International Meeting of The Institute of Human Virology

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Up-regulation of interferon-a/APOBEC3G signal pathway potently inactivates HIV-1 infectivity in resting CD4-T cells

Keyang Chen, Jialing Huang, Chune Zhang, Sophia Huang, Giuseppe Nunnari, Feng-xiang Wang, Xiangrong Tong, Ling Gao, Kristi Nikisher and Hui Zhang*

  • * Corresponding author: Hui Zhang

Author Affiliations

Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA

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Retrovirology 2006, 3(Suppl 1):P69  doi:10.1186/1742-4690-3-S1-P69

Published: 21 December 2006

First paragraph (this article has no abstract)

Interferon (IFN) system, including various IFNs and IFN-inducible gene products, is well known for its potent innate immunity against wide-range viruses. Recently, a family of cytidine deaminases, functioning as another innate immunity against retroviral infection, has been identified. However, its regulation remains largely unknown.