Commentary
The silent defense: Micro-RNA directed defense against HIV-1 replication
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Correspondence: Ajit Kumar akumar@gwu.edu
Department of Biochemistry & Molecular Biology, George Washington University, Washington, D.C, USA
Retrovirology 2007, 4:26 doi:10.1186/1742-4690-4-26
Published: 12 April 2007Abstract
MicroRNAs play critical role in regulating gene expression. MicroRNA profile of particular cell type bears the signature of cell type specific gene expression. Given that viral pathogens replicate by evading host defenses, research is now focused on the miRNA-regulated genes that critically regulate HIV-1 propagation in human host cells.