Table 3 |
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|
Human genes modulating HIV pathogenesis by influencing post-entry steps of the viral life cycle |
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|
Gene |
Allele or factor |
Mode |
Effect |
Mechanism of action |
Frequency(1) |
References |
|
|
||||||
|
CypA (PP1A) |
1650 G |
Recessive |
Delay AIDS |
Unknown |
Unknown |
12 |
|
TRIM5α |
Haplotype 9 |
Increase HIV transmission |
Unknown |
Caucasians (1%) |
182 |
|
|
TRIM5α |
136Q |
Dominant |
Protect against HIV infection |
136Q variant displays stronger anti-HIV activity |
African Americans (20%) |
183 |
|
TRIM5α |
43Y |
Dominant |
Protect against HIV infection |
Unknown |
African Americans (6.5%) |
183 |
|
APOBEC3G |
186R |
Recessive |
Accelerate AIDS |
Unknown |
African Americans (36.7%) |
206 |
|
APOBEC3G |
C40693T |
Unknown |
Increase HIV transmission |
Unknown (variant found in intronic region) |
Caucasians (< 1%) |
208 |
|
Cullin5 |
SNP6 A/G |
Dominant (additive) |
Accelerated CD4 T cell depletion and AIDS progression |
Unknown (the SNP6 G product displays stronger binding to nuclear proteins |
Africans (5%)(2) |
210 |
|
TSG101 |
-183C |
Dominant |
Accelerated CD4 T cell decline |
Increase virus budding? (paradoxically the -183C variant reduces replication in ex-vivo systems) |
Caucasians (17%) |
12, 229 |
|
|
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|
(1) Allele frequency in populations in which the variant is more predominant. (2) Higher allele frequencies are observed in European Americans (10%) and Chinese (20%), however the correlation is not observed in these populations. |
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|
Lama and Planelles Retrovirology 2007 4:52 doi:10.1186/1742-4690-4-52 |
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