|
Phenotypes of nef-deleted viruses isolated from SBBC members, and corresponding laboratory data |
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| Subject |
Virus isolate |
Date |
Years post-infection |
CD4 cells (cells/μl) |
HIV RNA (copies/ml) |
Replication in PBMC |
Coreceptor usage |
|
|
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| D36 |
D36II |
6/5/95 |
14.4 |
N/A |
1400 |
++ |
CCR5, CXCR4, (CCR2b) |
| D36III |
8/2/96 |
15.2 |
609 |
1100 |
++ |
NT |
|
| D36IV |
10/4/96 |
15.3 |
504 |
7700 |
++ |
NT |
|
| D36V |
9/7/96 |
15.6 |
414 |
2600 |
++ |
NT |
|
| D36VI |
23/10/96 |
15.8 |
432 |
1100 |
++ |
NT |
|
| D36VII |
30/1/97 |
16.1 |
361 |
3200 |
++ |
NT |
|
| D36VIII |
20/5/97 |
16.4 |
540 |
4000 |
++ |
CCR5, CXCR4, (CCR2b) |
|
| D36IX |
23/12/97 |
17.0 |
390 |
7500 |
++ |
CCR5, CXCR4, (CCR2b) |
|
| D36X |
15/7/98 |
17.6 |
325 |
N/A |
++ |
NT |
|
| D36XI |
22/1/99 |
18.1 |
N/A |
N/A |
++ |
CCR5, CXCR4, (CCR2b) |
|
| D36XVI |
8/11/00 |
19.9 |
N/A |
BD |
++ |
CCR5 |
|
|
|
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| C18 |
C18(2) |
26/7/93 |
9.8 |
N/A |
N/A |
+++ |
CCR5, (CCR3, Gpr15) |
| C18(3) |
14/10/93 |
10.1 |
N/A |
N/A |
+++ |
NT |
|
| C18(4) |
7/3/94 |
10.5 |
N/A |
2804 |
+++ |
CCR5, (CCR3, Gpr15) |
|
|
|
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| C54 |
C54III |
7/11/94 |
10.3 |
2006 |
8200 |
+/- |
CCR5, (CCR2b, CCR3) |
| C54IV |
21/6/95 |
10.9 |
1504 |
3000 |
+/- |
NT |
|
| C54 V |
20/12/95 |
11.4 |
1054 |
400 |
+/- |
NT |
|
| C54VI |
4/3/96 |
11.7 |
1188 |
1500 |
+/- |
NT |
|
| C54VII |
19/6/96 |
11.9 |
972 |
3600 |
+/- |
NT |
|
| C54VIII |
16/9/96 |
12.2 |
1120 |
1800 |
+/- |
CCR5, (CCR2b, CCR3) |
|
| C54X |
3/3/97 |
12.7 |
882 |
3400 |
+/- |
NT |
|
| C54XI |
14/5/97 |
12.8 |
1286 |
N/A |
+/- |
NT |
|
| C54XII |
11/8/97 |
13.1 |
1419 |
1700 |
+/- |
NT |
|
| C54XIII |
17/11/97 |
13.3 |
1054 |
N/A |
+/- |
NT |
|
| C54XIV |
5/5/99 |
14.8 |
1288 |
1200 |
+/- |
CCR5, (CCR2b, CCR3) |
|
| C54XV |
6/3/00 |
15.7 |
840 |
1600 |
+/- |
NT |
|
|
|
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| C98 |
C98II |
7/12/94 |
12.9 |
426 |
1000 |
++ |
CCR5, (CCR3) |
| C98III |
9/10/95 |
13.8 |
576 |
670 |
++ |
NT |
|
| C98IV |
7/2/96 |
14.1 |
435 |
200 |
++ |
NT |
|
| C98V |
22/5/96 |
14.3 |
693 |
290 |
++ |
NT |
|
| C98VI |
7/8/96 |
14.6 |
512 |
330 |
++ |
CCR5, (CCR2b, CCR3) |
|
| C98VII |
4/11/96 |
14.8 |
646 |
690 |
++ |
NT |
|
| C98VIII |
31/1/97 |
15.0 |
629 |
770 |
++ |
NT |
|
| C98IX |
7/5/97 |
15.3 |
529 |
760 |
++ |
NT |
|
| C98X |
27/8/97 |
15.6 |
612 |
170 |
++ |
NT |
|
| C98XI |
26/11/97 |
15.8 |
400 |
N/A |
++ |
NT |
|
| C98XII |
30/9/98 |
16.7 |
N/D |
N/A |
++ |
NT |
|
| C98XIII |
3/3/99 |
17.2 |
476 |
N/A |
++ |
NT |
|
| C98XIV |
9/11/99 |
17.8 |
585 |
BD |
++ |
CCR5, (CCR2b, CCR3) |
|
|
|
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| C64 |
C64IV |
28/2/96 |
12.8 |
850 |
BD |
+/- |
CCR5 |
|
Dates shown are day/month/year. CD4 cells were measured by flow cytometry. Plasma HIV-1 RNA was measured by COBAS Amplicor HIV-1 Monitor Version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.) prior to July 1999 and Version 1.5 after July 1999. HIV-1 RNA levels < 400 copies/ml (Version 1) or < 50 copies/ml (Version 1.5) were considered below detection. BD, below detection; N/A, not available; NT, not tested. +++, replication kinetics similar to wild type primary HIV strains; ++, reduced levels of replication and/or delayed replication kinetics compared to wild type primary HIV strains; +/-, levels of HIV replication barely detectable or not detectable by RT assays, but detectable by measurement of extracellular p24 antigen [40]. | |||||||
Gorry et al. Retrovirology 2007 4:66 doi:10.1186/1742-4690-4-66 |
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