Table 1

Assessment of macaque development and other infection characteristics.
Animal nomenclature and viral strains
 Body weight (kg)
 Plasma RNAVLs Log 10/copies/ml
 CD4 T cell counts (% of total peripheral lymphocytes)
 Lymph node VLs (SIV RNA copies/20 ng RNA)
 Testis VLs (SIV RNA copies/20 ng RNA)
 Epididymis VLs (SIV RNA copies/20 ng RNA)
 Maturation Status
M1SIVmac251
 6.75
 6.29
 7.9
 190
 600
 1150
 +++
M2SIVmac251
 6.50
 6.25
 8.1
 65 × 104
 110
 2200
 -
M3SIVmac251
 5.60
 5.97
 26.3
 260
 <50
 <50
 +
M4SIVmac251
 6.25
 7.33
 32.5
 <50
 385
 <50
 ++
M5SIVmac251
 5.30
 6.06
 17.4
 <50
 75
 <50
 -
M6SIVmac251
 7.20
 4.40
 30.0
 <50
 <50
 <50
 +++
M7SHIVmn229
 7.45
 5.48
 1.1
 1 × 103
 4000
 125
 +++
M8SHIVmn229
 5.80
 4.82
 1.5
 125 × 102
 55
 <50
 -
M9SHIVmn229
 4.30
 6.52
 0.4
 15 × 102
 90
 80
 -
M10SHIVmn229
 5.50
 4.77
 1.4
 13 × 103
 <50
 65
 ++
M11SHIVmn229
 7.35
 5.85
 0.4
 42 × 102
 <50
 150
 -
M12SHIVmn229
 4.80
 4.76
 0.3
 85 × 103
 <50
 <50
 ++

- animal is prepubertal (no active spermatogenesis)

+ animal is early pubertal (early meiotic cells only in the seminiferous epithelium)

++ animal is late pubertal (elongating spermatids in seminiferous tubules, but no sperm in epididymis)

+++ animal is sexually mature (full spermatogensis in the seminiferous tubules and sperm in the epididymal lumen)

VL-viral load; TCID50 = 50% Tissue Culture Infective Dose.

Shehu-Xhilaga et al. Retrovirology 2007 4:7   doi:10.1186/1742-4690-4-7

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