Table 2 |
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Summary of testicular and epididymal histology for SIV and SHIV-infected macaques |
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| Animal |
Spermatogenesis |
Testicular Interstitium |
Epididymis |
|
|
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| M1SIVmac251 |
Full spermatogenesis |
Normal macrophage numbers; no infiltrates |
Sperm in lumen; macrophages and small sized mononuclear cell infiltrates in stroma |
| M2SIVmac251 |
Spermatocytes and seminiferous cords only |
Small numbers of scattered mononuclear cells; macrophage numbers appear normal |
No cells in lumen; large sized mononuclear cell infiltrates in stroma; normal macrophage
numbers |
| M3SIVmac251 |
Some round spermatids present |
Few macrophages; no infiltrates |
No cells in lumen; numerous macrophages and focal mononuclear cell infiltrates |
| M4SIVmac251 |
Elongating spermatids present; some tubules with lumen |
Normal macrophage numbers; no infiltrates |
Sperm and many spermatocytes and round spermatids in lumen; several very large mononuclear
cell infiltrates in stroma |
| M5SIVmac251 |
Spermatocytes and seminiferous cords only |
Minor mononuclear cell infiltrates; macrophage numbers appear normal |
No cells in lumen; medium sized mononuclear cell infiltrates in stroma; normal macrophage
numbers |
| M6SIVmac251 |
Full spermatogenesis |
Normal macrophage numbers; no infiltrates |
Sperm in lumen; no stromal infiltrates |
| M7SHIVmn229 |
Full spermatogenesis |
Normal macrophage numbers; no infiltrates |
Sperm in lumen; numerous macrophages and scattered mononuclear cell infiltrates |
| M8SHIVmn229 |
Spermatogonia and seminiferous cords only |
Few macrophages; no infiltrates |
No cells in lumen; no stromal infiltrates |
| M9SHIVmn229 |
Spermatogonia and seminiferous cords only |
Few macrophages; no infiltrates |
No cells in lumen; no stromal infiltrates |
| M10SHIVmn229 |
Elongating spermatids present; some tubules with lumen |
Normal macrophage numbers; no infiltrates |
No cells in lumen; numerous macrophages and scattered mononuclear cell infiltrates |
| M11SHIVmn229 |
Spermatogonia and seminiferous cords only |
Numerous macrophages in the interstitium and some focal mononuclear cell infiltrates |
No cells in lumen; no stromal infiltrates |
| M12SHIVmn229 |
Elongating spermatids present; spermatogenesis is disorganised |
Normal macrophage numbers; no infiltrates |
No sperm in lumen; degenerating spermatocytes and round spermatids in lumen; no stromal
infiltrates |
|
|
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Shehu-Xhilaga et al. Retrovirology 2007 4:7 doi:10.1186/1742-4690-4-7 |
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