Detection, characterization and regulation of antisense transcripts in HIV-1
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* Corresponding author: Benoit Barbeau barbeau.benoit@uqam.ca
Retrovirology 2007, 4:71 doi:10.1186/1742-4690-4-71
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Research
Isabelle Clerc, Sylvain Laverdure, Cynthia Torresilla, Sébastien Landry, Sophie Borel, Amandine Vargas, Charlotte Arpin-André, Bernard Gay, Laurence Briant, Antoine Gross, Benoît Barbeau, Jean-Michel Mesnard Retrovirology 2011, 8:74 (19 September 2011) Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' LTR, which is either left unspliced or alternatively spliced. We and others have demonstrated the existence of antisense transcription initiating in the 3' LTR in human lymphotropic retroviruses, including HTLV-1, HTLV-2, and HIV-1. Such transcripts have been postulated to encode antisense proteins important for the establishment of viral infections. The antisense strand of the HIV-1 proviral DNA contains an ORF termed asp, coding for a highly hydrophobic protein. However, although anti-ASP antibodies have been described to be present in HIV-1-infected patients, its in vivo expression requires further support. The present study demonstrates that ASP is effectively expressed in infected T cells and characterize its subcellular localization.
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Research
David M Sintasath, Nathan D Wolfe, Hao Zheng, Matthew LeBreton, Martine Peeters, Ubald Tamoufe, Cyrille F Djoko, Joseph LD Diffo, Eitel Mpoudi-Ngole, Walid Heneine, William M Switzer Retrovirology 2009, 6:97 (27 October 2009) |
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Review
The HBZ gene, a key player in HTLV-1 pathogenesis Masao Matsuoka, Patrick L Green Retrovirology 2009, 6:71 (3 August 2009) |
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Commentary
Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions? Man Yeung, Monsef Benkirane, Kuan-Teh Jeang Retrovirology 2007, 4:74 (15 October 2007) |