Figure 1.

Schematic representations of positive and negative regulation mediated through ncRNA-guide sequences. RBPx is to illustrate a negative multi-RNA-binding protein regulatory complex that is tagged by a ncRNA-guide and recruited based on sequence-complementarity to target; while RBPy is to represent a theoretical positive multi-RNA-binding protein complex. PTGS, post-transcriptional gene silencing; TGS, transcriptional gene silencing; CTGS, co-transcriptional gene silencing. Currently, while there are many examples of RBPx, there is yet little published evidence for RBPy.