Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)

doi:10.1186/1742-4690-4-91

Retrovirology

Volume 4

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Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)

Jia Hai Lee , Venkat RK Yedavalli and Kuan-Teh Jeang

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USA

author email corresponding author email

Retrovirology 2007, 4:91doi:10.1186/1742-4690-4-91


Published:	13 December 2007

Abstract

The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3. Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP agonists and cGMP antagonists caused respectively increased and decreased virus replication. These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells.