Table 1

Genes with predicted simultaneous seed matches for miR-21, miR-24, miR-146a and miR-155.

Gene

Seed matches for miR

Seed matches in other databases

Gene ontology (GO) terms for biological processes

21

24

146a

155

SH3TC2

1

2

3

3

155¹

signal transduction

ITGB3

3

2

3

1

-

cell adhesion

MMP16

2

1

2

3

24^1,2, 146a¹, 155³

-

PURB

2

2

2

2

21^1,2, 24^1,2

regulation of myeloid cell differentiation

FAM130A1

1

1

3

2

155³

positive regulation of transcription

SMAD5

2

1

3

1

-

signal transduction (TGF-β)

ONECUT2

2

2

1

2

146a³

organ morphogenesis

DCX

1

2

1

2

-

CNS development

EIF2C4

2

1

2

1

-

chromatin silencing

CBFA2T2

1

2

1

2

-

negative regulation of transcription

JHDM1D

3

1

1

1

21³

-

SLC12A6

1

1

1

2

24^1,2,3, 155³

cell volume homeostasis

ZNF532

1

1

2

1

146a¹

-

TP53INP1

2

1

1

1

24^1,2, 155^1,2,3

-

KIAA1128

2

1

1

1

-

-

CLCN5

2

2

1

1

24¹

excretion

FLJ25778

1

1

2

1

-

-

CREBL2

1

1

1

2

21^1,2, 24^1,2, 146a³

signal transduction transcription

RFXDC2

1

1

1

2

146a^1,3

-

YOD1

1

1

1

2

21¹, 24¹

amino acid metabolic process

VGLL3

2

1

2

1

24³

-

PPM1D

1

1

1

2

-

negative regulation of cell proliferation

CYBB

1

2

1

2

-

innate immune response, inflammatory resp

RP11-93B10.1

1

1

1

1

24³, 146a^1,2, 155¹

-

COL19A1

1

1

1

1

155³

-

LOC348120

1

1

1

1

-

-

AFF1

1

1

1

1

-

transcription

RDX

1

1

1

1

-

-

RIT1

1

1

1

1

21¹, 24¹, 155

signal transduction

USP31

1

1

1

1

-

-

ARHGEF1

1

1

1

1

21³

cell proliferation

SERTAD2

1

1

1

1

155¹

negative regulation of cell growth

In silico analysis (microRNA.org) of genes carrying at least one binding site for each of the four microRNAs. Results were compared to those obtained from other databases (TargetScan, PicTar, mirDB) and hits listed in column "Seed matches in other databases".

¹TargetScan, ²PicTar, ³mirDB

Pichler et al. Retrovirology 2008 5:100   doi:10.1186/1742-4690-5-100