MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

doi:10.1186/1742-4690-5-118

Retrovirology

Volume 5

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MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

Laurent Houzet¹^* , Man Lung Yeung¹^* , Valery de Lame² , Dhara Desai² , Stephen M Smith² and Kuan-Teh Jeang¹

¹Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

²Department of Infectious Diseases, Saint Michael's Medical Center, Newark, New Jersey, 07102, USA

author email corresponding author email* Contributed equally

Retrovirology 2008, 5:118doi:10.1186/1742-4690-5-118


Published:	29 December 2008

Abstract

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.