Figure 2.

Presence of potential HIV target cells in the human prostate. Immunohistochemistry on uninfected prostate sections before culture showed the presence of periglandular foci of HLA-DR+ (A) and CD4+ cells (B, serial section with A) as well as scattered stromal cells staining positive for HLA-DR (A), CD4 (B), CD3 (C), CD68 (D), CCR5 (E) and CXCR4 (F). The arrows point out immune cells inserted within the epithelium-Scale bars = 50 μm; (G): the respective proportions of CD3, CD4, CD68, CXCR4 and CCR5+ cells per surface unit were evaluated on whole prostate sections from a minimum of 3 donors whose explants were subsequently exposed to HIV-1 strains.