Retrovirology
Volume 5
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  CommentaryRNA interference: a multifaceted innate antiviral defenseAjit Kumar  Department of Biochemistry and Molecular Biology. George Washington University School of Medicine. 2300 I Street, N.W. Washington, D.C 20037, USA  author email corresponding author email
Retrovirology 2008,
5:17doi:10.1186/1742-4690-5-17
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| Published: |
1 February 2008 |
Abstract
The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of viral restriction guided by RNA-based defenses, as well as the full physiological implication of host-pathogen engagement, constitute exciting areas of investigation in the biology of non-coding RNAs. | 
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