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Open Access Highly Accessed Review

6th International Symposium on Retroviral Nucleocapsid

Ben Berkhout1, Robert Gorelick2, Michael F Summers3, Yves Mély4 and Jean-Luc Darlix5*

Author Affiliations

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA) Academic Medical Center of the University of Amsterdam K3-110, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

2 AIDS Vaccine Program SAIC-Frederick, Inc. NCI-Frederick P.O. Box B Frederick, MD 21702-1201, USA

3 Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA

4 Départment Pharmacologie et Physico-chimie, UMR 7175 CNRS, Institut Gilbert Laustriat, Université Louis Pasteur, 74 route du Rhin, 67401 Illkirch, France

5 LaboRetro INSERM #758, Ecole Normale Supérieure de Lyon, IFR 128 Biosciences Lyon-Gerland, 69364 Lyon Cedex 07, France

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Retrovirology 2008, 5:21  doi:10.1186/1742-4690-5-21

Published: 25 February 2008

Abstract

Retroviruses and LTR-retrotransposons are widespread in all living organisms and, in some instances such as for HIV, can be a serious threat to the human health. The retroviral nucleocapsid is the inner structure of the virus where several hundred nucleocapsid protein (NC) molecules coat the dimeric, genomic RNA. During the past twenty years, NC was found to play multiple roles in the viral life cycle (Fig. 1), notably during the copying of the genomic RNA into the proviral DNA by viral reverse transcriptase and integrase, and is therefore considered to be a prime target for anti-HIV therapy. The 6th NC symposium was held in the beautiful city of Amsterdam, the Netherlands, on the 20th and 21st of September 2007. All aspects of NC biology, from structure to function and to anti-HIV vaccination, were covered during this meeting.