Figure 2.

Potential targets of APOBEC3G and APOBEC3F cytidine deaminase activity within HIV-1 protease. Positions highlighted in blue, yellow, and green are encoded by codons that are targets of APOBEC3G, APOBEC3F, and both factors, respectively. Red stars indicate targeted positions involved in antiretroviral resistance [35]. Recognized CTL epitopes and the HLA alleles that are believed to target these regions are listed (based on prediction algorithms and/or direct experimental validation, as presented in the HIV Molecular Immunology Database [40]).