Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

doi:10.1186/1742-4690-5-33

Retrovirology

Volume 5

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Freer G
Matteucci D
Mazzetti P
Tarabella F
Ricci E
Bozzacco L
Merico A
Pistello M
Ceccherini-Nelli L
Bendinelli M

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Freer G
Matteucci D
Mazzetti P
Tarabella F
Ricci E
Bozzacco L
Merico A
Pistello M
Ceccherini-Nelli L
Bendinelli M
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Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

Giulia Freer^* , Donatella Matteucci^* , Paola Mazzetti , Francesca Tarabella , Enrica Ricci , Leonia Bozzacco , Antonio Merico , Mauro Pistello , Luca Ceccherini-Nelli and Mauro Bendinelli

Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via del Brennero 2, I-56127 Pisa, Italy

author email corresponding author email* Contributed equally

Retrovirology 2008, 5:33doi:10.1186/1742-4690-5-33


Published:	17 April 2008

Abstract

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4⁺T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.