Commentary
APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
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* Corresponding author: Klaus Strebel kstrebel@niaid.nih.gov
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4/312, Bethesda, MD, 20892-0460, USA
Retrovirology 2008, 5:55 doi:10.1186/1742-4690-5-55
Published: 2 July 2008Abstract
APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.