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APOBEC3G encapsidation into HIV-1 virions: which RNA is it?

Klaus Strebel email and Mohammad A Khan email

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4/312, Bethesda, MD, 20892-0460, USA

author email corresponding author email

Retrovirology 2008, 5:55doi:10.1186/1742-4690-5-55

Published: 2 July 2008

Abstract

APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.


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