Table 3

Calculated ΔG values (kcal/mol at 37°C) for lentiviral SL1 region folding.

SL1 version

nts folded

ΔG

HIV-2

short

408–436

-10.2

HIV-2

stem B

392–444

-18.2

HIV-2

extended stem B

392–449 ^a

-36.4

SIV

short

409–433

-7

SIV

stem B

393–445

-15.9

HIV-1

short

248–270

-6.7

HIV-1

stem B

243–277

-10.9 ^b

The indicated energies are given for the most stable (initial ΔG value) secondary structure.

a: nts 437 and 438 have been substituted by seven nts (Figure 6C). Thus nt 444 would be numbered 449 in this mutated sequence.

b: The indicated energy is given for the structure described in Figure 5C that was obtained with a constrained 243–277 base pair. Without constraint, the lower part of stem C in the most stable structure folds with a 243–272 base pair (as studied in [48]).

Baig et al. Retrovirology 2008 5:65   doi:10.1186/1742-4690-5-65