SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys

doi:10.1186/1742-4690-5-94

Retrovirology

Volume 5

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Humbert M
Rasmussen RA
Song R
Ong H
Sharma P
Chenine AL
Kramer VG
Siddappa NB
Xu W
Else JG
Novembre FJ
Strobert E
O'Neil SP
Ruprecht RM

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Humbert M
Rasmussen RA
Song R
Ong H
Sharma P
Chenine AL
Kramer VG
Siddappa NB
Xu W
Else JG
Novembre FJ
Strobert E
O'Neil SP
Ruprecht RM
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Short report

SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys

Michael Humbert¹^,2 , Robert A Rasmussen¹^,2 , Ruijiang Song¹^,2 , Helena Ong¹ , Prachi Sharma³ , Agnès L Chenine¹^,2 , Victor G Kramer¹ , Nagadenahalli B Siddappa¹^,2 , Weidong Xu¹^,2 , James G Else³ , Francis J Novembre³ , Elizabeth Strobert³ , Shawn P O'Neil²^,4 and Ruth M Ruprecht¹^,2

¹Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA

²Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA

³Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA, 30329, USA

⁴New England Primate Research Center, PO Box 9102, Southborough, MA 01772, USA

author email corresponding author email

Retrovirology 2008, 5:94doi:10.1186/1742-4690-5-94


Published:	17 October 2008

Additional files

Additional file 1:

Mycobacteriosis in RPn-8. Histopathological examination of mesenteric lymph node. The lymph node parenchyma is effaced with large numbers of epitheloid macrophages (arrows).

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Additional file 2:

Pneumocystis pneumonia in RPn-8. The pulmonary alveoli are filled with a foamy exudate (arrows).

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Additional file 3:

HE of trachea of RPn-8. Cryptosporidial organisms (arrows) on the luminal surface of the tracheal mucosa.

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Additional file 4:

Lymphocryptovirus infection of the tongue of RPn-8. Epstein Barr virus-like inclusions (arrows) in the epithelium.

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Additional file 5:

Immunohistochemistry for diagnosis of rhesus lymphocryptovirus infection. (A) Section of tongue from rhesus macaque RPn-8, shown at low magnification (200×) after staining with hematoxylin and eosin (H&E). (B) Higher magnification of A (400×), showing EBV-like intranuclear inclusions (arrows). (C) Higher magnification of Figure 4D (400×), showing intranuclear localization of EBNA 2 expression.

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Additional file 6:

HE of the brain of RKl-8. Detailed pictures from Figure 4A. (A) Meningoencephalitis (20×). (B) Rarefaction (arrows) of the cerebral white matter (20×).

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Additional file 7:

Diagnosis of SV40 meningoencephalitis in RKl-8. (A-C) IHC for SV40 large T antigen, revealing swollen, immunoreactive glial nuclei (brown chromogen) within encephalitic regions (A; with inflammatory cell infiltrate indicated by arrow) or in normal brain parenchyma (B and C) adjacent to areas of inflammation. (D) Lower magnification view showing a single SV40 positive cell by ISH (asterisk) adjacent to a perivascular cuff of inflammatory cells (arrow) within a region of inflammation and demyelination.

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Additional file 8:

HE of colon (A) and kidney (B) of RKl-8. (A) Arteriopathy marked by intimal thickening and fibrosis. (B) Vascular changes in renal parenchyma.

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Additional file 9:

HE of RKl-8. A recannalized thrombus in a blood vessel in the mesentery of the colon.

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