Additional file 7.

Diagnosis of SV40 meningoencephalitis in RKl-8. (A-C) IHC for SV40 large T antigen, revealing swollen, immunoreactive glial nuclei (brown chromogen) within encephalitic regions (A; with inflammatory cell infiltrate indicated by arrow) or in normal brain parenchyma (B and C) adjacent to areas of inflammation. (D) Lower magnification view showing a single SV40 positive cell by ISH (asterisk) adjacent to a perivascular cuff of inflammatory cells (arrow) within a region of inflammation and demyelination.

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Humbert et al. Retrovirology 2008 5:94   doi:10.1186/1742-4690-5-94