This article is part of the supplement: Fourth Dominique International Conference. Maternal chronic viral infections transmitted to infants: from mechanisms to prevention and care Oral presentationBile-salt stimulated lipase in human milk binds DC-SIGN and inhibits HIV-1 transmission1Laboratory of Experimental Virology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, the Netherlands 2Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, the Netherlands 3Department of Clinical Sciences, Umea University, SE-901 87 Umea, Sweden
from Fourth Dominique Dormont International Conference. Host-Pathogen Interactions in Chronic Infections Retrovirology 2008, 5(Suppl 1):O3doi:10.1186/1742-4690-5-S1-O3
First paragraph (this article has no abstract)Approximately 20% of HIV-1 infected breastfeeding mothers transmit virus to their infants. It has been hypothesized that dendritic cells expressing C-type lectins, such as DC-SIGN, play an important role in the establishment of infection with HIV-1 and several other pathogens. |
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