Table 3 |
|||
|
EC50 values for RAL, MK-2048 and EVG for subtype B and C viruses cultured in cord blood mononuclear cells. |
|||
|
Subtype B |
EC50 Values (μM) |
||
|
|
|||
|
Viruses |
RAL (μM) |
MK-2048 (μM) |
EVG (μM) |
|
|
|||
|
5326 |
0.0243 ± 0.0025 |
0.0072 ± 0.0021 |
NDa |
|
5331 |
0.0056 ± 0.0022 |
0.0010 ± 0.0002 |
0.0001 ± 0.00007 |
|
BK 132 |
0.0301 ± 0.0054 |
0.0148 ± 0.0032 |
NDa |
|
pNL4-3 |
0.0082 ± 0.0013 |
0.0027 ± 0.0009 |
0.0009 ± 0.0003 |
|
IIIb |
0.0012 ± 0.0005 |
0.0003 ± 0.0001 |
0.0018 ± 0.0006 |
|
Subtype C |
EC50 Values (μM) |
||
|
|
|||
|
Viruses |
RAL (μM) |
MK-2048 (μM) |
EVG (μM) |
|
|
|||
|
Mole 03 |
0.0046 ± 0.0002 |
0.0011 ± 0.0001 |
NDa |
|
96USNG31 |
0.0087 ± 0.0007 |
0.0015 ± 0.0001 |
0.0008 ± 0.0006 |
|
4742 |
0.0206 ± 0.0090 |
0.0033 ± 0.0020 |
0.0022 ± 0.0002 |
|
BG-05 |
0.0067 ± 0.0009 |
0.0022 ± 0.0007 |
0.0008 ± 0.00004 |
|
HB-1 |
0.0015 ± 0.0004 |
0.0007 ± 0.0005 |
0.0001 ± 0.00001 |
|
|
|||
|
aND = not done |
|||
|
Bar-Magen et al. Retrovirology 2009 6:103 doi:10.1186/1742-4690-6-103 |
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