Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
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* Corresponding author: Carine Van Lint cvlint@ulb.ac.be
Retrovirology 2009, 6:111 doi:10.1186/1742-4690-6-111
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Research
Brian Murphy, Natasha Vapniarsky, Chad Hillman, Diego Castillo, Samantha McDonnel, Peter Moore, Paul A Luciw, Ellen E Sparger Retrovirology 2012, 9:12 (7 February 2012) This study shows that viral LTR and gag sequences amplified from peripheral blood mononuclear cells during early and chronic stages of infection demonstrated minimal to no viral sequence variation consistent with tight transcriptional latency in FIV infection in vivo.
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Review
The role of unintegrated DNA in HIV infection Richard D Sloan, Mark A Wainberg Retrovirology 2011, 8:52 (1 July 2011) Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various viral unintegrated DNA forms exist in abundance. Though linear viral cDNA is the precursor to integrated provirus, increasing evidence suggests that transcription and translation of unintegrated DNAs prior to integration may aid productive infection through the expression of early viral genes. Additionally, unintegrated DNA has the capacity to result in preintegration latency, or to be rescued and yield productive infection and so unintegrated DNA, in some circumstances, may be considered to be a viral reservoir. Recently, there has been interest in further defining the role and function of unintegrated viral DNAs, in part because the use of anti-HIV integrase inhibitors leads to an abundance of unintegrated DNA, but also because of the potential use of non-integrating lentiviral vectors in gene therapy and vaccines. There is now increased understanding that unintegrated viral DNA can either arise from, or be degraded through, interactions with host DNA repair enzymes that may represent a form of host antiviral defence. This review focuses on the role of unintegrated DNA in HIV infection and additionally considers the potential implications for antiviral therapy.
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Research
An RNAi in silico approach to find an optimal shRNA cocktail against HIV-1 María C Méndez-Ortega, Silvia Restrepo, Luis M Rodríguez-R, Iván Pérez, Juan C Mendoza, Andrés P Martínez, Roberto Sierra, Gloria J Rey-Benito Virology Journal 2010, 7:369 (20 December 2010) |