Table 1 |
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Chromatin-modifying enzymes. |
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a. HDACs (Histone deacetylases) |
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Family |
Members |
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Class I |
HDAC-1; HDAC-2; HDAC-3; HDAC-8 |
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Class Iia |
HDAC-4; HDAC-5; HDAC-7; HDAC-9 |
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Class IIb |
HDAC-6; HDAC-10 |
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Class III |
SIRT1; SIRT2; SIRT3; SIRT4; SIRT5; SIRT6; SIRT7 |
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Class IV |
HDAC-11 |
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b. HATs (Histone acetyltransferases) |
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Family |
Members |
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GNAT |
Gcn5; ELP3; HAT1; PCAF |
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p300/CBP |
p300; CBP |
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MYST |
ESA1; CLOCK; MOF/MYST1; HBO1/MYST2; MOZ/MYST3/HAT3; MORF/MYST4; SAS2; TIP60; YBF2/SAS3 |
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Others |
ACTR; ATF-2; GRIP; p/CIP; SRC1; TAF1; TFIIB |
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c. HMTs (Histone methyltransferases) |
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Family |
Members |
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HKMTs |
ALL-1; ALR; AsH1; DOT1L; ESET/SETDB1; EuHMTase/GLP; EZH2; G9a; MLL1; MLL2; MLL3; MLL4; MLL5; NSD1; RIZ1; SET1; SET2; SET 7/8; SET7/9; SMYD2; SMYD3; Suv39 h1; Suv39H2; Suv4-20H1; Suv4-20H2 |
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PRMTs |
PRMT1; PRMT2; PRMT3; PRMT4/CARM1; PRMT5/JBP1; PRMT6 |
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d. HDMTs (Histone demethylases) |
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Family |
Members |
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LSD1 |
LSD1 |
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JHDM/Jumonji |
JARID1A/RBP-2; JARID1B/PLU-1; JARID1C/SMCX; JARID1D/SMCY; JHDM1a; JHDM1b; JHDM2a; JHDM2b; JMJD2A; JMJD2B; JMJD2C; JMJD2D; JMJD3 |
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e. DNMTs (DNA methyltransferases) |
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Family |
Members |
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Maintenance |
DNMT1 |
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DNMT2 |
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De novo |
DNMT3a; DNMT3b; DNMT3l |
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This table summarizes the main family members of HDACs (panel a), HATs (panel b), HMTs (panel c), HDMTs (panel d) and DNMTs (panel e). To facilitate comprehension, enzymes that appear in the text of this review are indicated in bold. Abbreviations used in table 1: ACTR: Activator of thyroid and retinoic acid receptors; ALL-1: acute lymphoblastic leukemia; ALR: ALL-1 related gene; AsH1: absent small or homeotic discs1; ATF-2: Activating Transcription Factor; CARM1: coactivator-associated arginine methyltransferase 1; CBP: CREB binding protein; DOT1: disrupter of telomeric silencing; ELP3: elongation protein 3 homolog; ESET: SET domain bifurcated 1; Eu-HMTase: euchromatic histone methyltransferase 1; EZH2: enhancer of zeste homolog 2; Gcn5: General control nuclear factor 5; GNAT: Gcn5-related N-AcetylTransferase; GRIP: glucocorticoid receptor-interacting protein 1; HBO1: HAT bound to DNA replication origin complex; HKMT: Histone methyltransferase; JARID: Jumonji, AT rich interactive domain; JHDM: JmjC domain containing histone demethylases; JMJD: Jumonji-domain containing; LSD1: lysine-specific demethylase 1; MLL: Mixed-lineage leukemia; JBP1: Janus kinase binding protein 1; MOF: males absent on the first; MORF: MOZ-related factor; MOZ: Monocyte leukemia zinc-finger protein; MYST: named for its founding members MOZ, YBF2/SAS3, SAS2, and Tip60; NSD1: nuclear receptor binding SET domain protein 1; p/CAF: p300/CBP associated factor; p/CIP: p300/CBP interacting protein; PRMT: Protein arginine methyltransferase; RBP-2: retinol-binding protein 2; RIZ1: retinoblastoma protein-interacting zinc-finger 1; SAS2: serum antigenic substance 2; SET1: SET domain containing 1; SETDB1: SET domain bifurcated 1; SIRT: Sirtuin; SMC: Structural Maintenance of Chromosomes-1; SMYD: SET- and MYND-domain-containing; SRC: Steroid receptor coactivator; Suv39 h1: suppressor of variegation 3-9 homolog 1; Suv4-20 h1: suppressor of variegation 4-20 h1; TAF1: TATA-binding protein (TBP)-associated factor; TFIIB: Transcription factor IIB; TIP60: Tat interacting protein (60 kD). |
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Colin and Van Lint Retrovirology 2009 6:111 doi:10.1186/1742-4690-6-111 |
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