APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA
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* Corresponding author: Vinay K Pathak vpathak@ncifcrf.gov
Retrovirology 2009, 6:16 doi:10.1186/1742-4690-6-16
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Human cellular restriction factors that target HIV-1 replication Klaus Strebel, Jeremy Luban, Kuan-Teh Jeang BMC Medicine 2009, 7:48 (16 September 2009) Although different host cell factors act to inhibit viral replication and limit infection, HIV-1 has a number of measures to counteract this function; Strebel, Luban and Jeang review our current understanding of these interactions.
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