Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?
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Correspondence: Alan Cochrane alan.cochrane@utoronto.ca
Retrovirology 2009, 6:22 doi:10.1186/1742-4690-6-22
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Research
Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression Venkat SRK Yedavalli, Kuan-Teh Jeang Retrovirology 2011, 8:61 (20 July 2011) Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.
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