Retrovirology

official impact factor 5.24

Open Access

Induction of p21CIP1/WAF1 expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

Ling Zhang, Huijun Zhi, Meihong Liu, Yu-Liang Kuo and Chou-Zen Giam*

Retrovirology 2009, 6:35 doi:10.1186/1742-4690-6-35

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Commentary   Open Access

How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells

Mathieu Boxus, Luc Willems Retrovirology 2012, 9:2 (5 January 2012)

How the Human T lymphotropic virus type 1 (HTLV-1) Tax protein stimulates proliferation while triggering cell cycle arrest and senescence remains puzzling. There is also a debate about the ability of Tax to activate or inhibit the DNA damage response. Here, it is discussed how to rationalize apparently conflicting observations.

Review   Open Access Highly Accessed

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

Masaya Higuchi, Masahiro Fujii Retrovirology 2009, 6:117 (17 December 2009)