HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
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* Corresponding author: Li Wu liwu@mcw.edu
Retrovirology 2009, 6:51 doi:10.1186/1742-4690-6-51
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BioMed Central: 4 citations
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SAMHD1: a new insight into HIV-1 restriction in myeloid cells Corine St Gelais, Li Wu Retrovirology 2011, 8:55 (8 July 2011) Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.
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Review
The macrophage in HIV-1 infection: From activation to deactivation? Georges Herbein, Audrey Varin Retrovirology 2010, 7:33 (9 April 2010) |
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Review
Host hindrance to HIV-1 replication in monocytes and macrophages Anna Bergamaschi, Gianfranco Pancino Retrovirology 2010, 7:31 (7 April 2010) |
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Review
Laurence Colin, Carine Van Lint Retrovirology 2009, 6:111 (4 December 2009) |