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"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

Andrea Savarino*†, Antonello Mai†, Sandro Norelli, Sary El Daker, Sergio Valente, Dante Rotili, Lucia Altucci, Anna T Palamara and Enrico Garaci

Retrovirology 2009, 6:52 doi:10.1186/1742-4690-6-52

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Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy

Mark G Lewis, Sandro Norelli, Matt Collins, Maria Barreca, Nunzio Iraci, Barbara Chirullo, Jake Yalley-Ogunro, Jack Greenhouse, Fausto Titti, Enrico Garaci, Andrea Savarino Retrovirology 2010, 7:21 (16 March 2010)

Abstract | Full text | PDF | PubMed | 1 comment | Editor’s summary

The integrase strand transfer inhibitor raltegravir effectively inhibits SIV replication and combined with existing antiretroviral drugs could represent a new generation of ART capable of clearing virus from the body.

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Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

Laurence Colin, Carine Van Lint Retrovirology 2009, 6:111 (4 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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