The HBZ gene, a key player in HTLV-1 pathogenesis
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* Corresponding author: Patrick L Green green.466@osu.edu
Retrovirology 2009, 6:71 doi:10.1186/1742-4690-6-71
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BioMed Central: 4 citations
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Editorial
The 2011 Retrovirology Prize winner Masao Matsuoka: forward looking and antisense Kuan-Teh Jeang Retrovirology 2011, 8:102 (15 December 2011) Masao Matsuoka wins the 2011 Retrovirology Prize
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Review
Fabiola Martin, Charles RM Bangham, Vincenzo Ciminale, Michael D Lairmore, Edward L Murphy, William M Switzer, Renaud Mahieux Retrovirology 2011, 8:86 (28 October 2011) This report summarizes presentations made at the June 2011, 15th International Conference on Human Retrovirology: HTLV and Related Viruses.
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Research
Isabelle Clerc, Sylvain Laverdure, Cynthia Torresilla, Sébastien Landry, Sophie Borel, Amandine Vargas, Charlotte Arpin-André, Bernard Gay, Laurence Briant, Antoine Gross, Benoît Barbeau, Jean-Michel Mesnard Retrovirology 2011, 8:74 (19 September 2011) Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' LTR, which is either left unspliced or alternatively spliced. We and others have demonstrated the existence of antisense transcription initiating in the 3' LTR in human lymphotropic retroviruses, including HTLV-1, HTLV-2, and HIV-1. Such transcripts have been postulated to encode antisense proteins important for the establishment of viral infections. The antisense strand of the HIV-1 proviral DNA contains an ORF termed asp, coding for a highly hydrophobic protein. However, although anti-ASP antibodies have been described to be present in HIV-1-infected patients, its in vivo expression requires further support. The present study demonstrates that ASP is effectively expressed in infected T cells and characterize its subcellular localization.
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Review
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis Masaya Higuchi, Masahiro Fujii Retrovirology 2009, 6:117 (17 December 2009) |