Table 1

Selected HIV-1 cofactors identified in the siRNA and shRNA screens

Gene name

Protein function

Possible role in HIV-1 life cycle

MED4

mediator complex subunit

Tat-dependent activation of LTR

MED7

mediator complex subunit

Tat-dependent activation of LTR

MED14

mediator complex subunit

Tat-dependent activation of LTR

MED28

mediator complex subunit

Tat-dependent activation of LTR

NUP98

nucleoporin

nuclear import/export of viral nucleic acids and proteins

NUP155

nucleoporin

nuclear import/export of viral nucleic acids and proteins

NUP210

nucleoporin

nuclear import/export of viral nucleic acids and proteins

GCC1

peripheral Golgi protein

processing of viral proteins

GOLM1

Golgi transmembrane protein

processing of viral proteins

GOSR2

Golgi membrane protein

processing of viral proteins

Kok et al. Retrovirology 2009 6:78   doi:10.1186/1742-4690-6-78