Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome
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* Corresponding author: Kathleen Boris-Lawrie boris-lawrie.1@osu.edu
Retrovirology 2009, 6:8 doi:10.1186/1742-4690-6-8
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BioMed Central: 5 citations
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Ioana Boeras, Michael Sakalian, John T West Retrovirology 2012, 9:8 (25 January 2012) This paper shows that the translation of MMTV Gag mRNA is negatively regulated by a nuclear "experience" and that viral Rem protein, viral RmRE sequence,and a splice donor and acceptor are needed to counter the negative translational effect on Gag mRNA in the cytoplasm.
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Proceedings
Dukyong Yoon, Hyosil Kim, Haeyoung Suh-Kim, Rae Woong Park, KiYoung Lee BMC Systems Biology 2011, 5(Suppl 2):S1 (14 December 2011) |
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Research
Isabelle Clerc, Sylvain Laverdure, Cynthia Torresilla, Sébastien Landry, Sophie Borel, Amandine Vargas, Charlotte Arpin-André, Bernard Gay, Laurence Briant, Antoine Gross, Benoît Barbeau, Jean-Michel Mesnard Retrovirology 2011, 8:74 (19 September 2011) Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' LTR, which is either left unspliced or alternatively spliced. We and others have demonstrated the existence of antisense transcription initiating in the 3' LTR in human lymphotropic retroviruses, including HTLV-1, HTLV-2, and HIV-1. Such transcripts have been postulated to encode antisense proteins important for the establishment of viral infections. The antisense strand of the HIV-1 proviral DNA contains an ORF termed asp, coding for a highly hydrophobic protein. However, although anti-ASP antibodies have been described to be present in HIV-1-infected patients, its in vivo expression requires further support. The present study demonstrates that ASP is effectively expressed in infected T cells and characterize its subcellular localization.
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Research
Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression Venkat SRK Yedavalli, Kuan-Teh Jeang Retrovirology 2011, 8:61 (20 July 2011) Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.
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Minireview
Human cellular restriction factors that target HIV-1 replication Klaus Strebel, Jeremy Luban, Kuan-Teh Jeang BMC Medicine 2009, 7:48 (16 September 2009) Although different host cell factors act to inhibit viral replication and limit infection, HIV-1 has a number of measures to counteract this function; Strebel, Luban and Jeang review our current understanding of these interactions.
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