Inhibition of HIV-1 expression and replication by SOFA-HDV ribozymes against Tat and Rev mRNA sequences

doi:10.1186/1742-4690-6-S2-P47

Retrovirology

Volume 6
Suppl 2

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Lainé S
Scarborough RJ
Lévesque D
Didierlaurent L
Soye KJ
Mougel M
Perreault JP
Gatignol A

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Scarborough RJ
Lévesque D
Didierlaurent L
Soye KJ
Mougel M
Perreault JP
Gatignol A
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This article is part of the supplement: Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts .

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Inhibition of HIV-1 expression and replication by SOFA-HDV ribozymes against Tat and Rev mRNA sequences

Sébastien Lainé¹^,2^,4, Robert J Scarborough¹^,2, Dominique Lévesque⁵, Ludovic Didierlaurent⁶, Kaitlin J Soye¹^,2, Marylène Mougel⁶, Jean-Pierre Perreault⁵ and Anne Gatignol¹^,2^,3

¹Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical Research, McGill University, Montréal, Canada

²Department of Microbiology and Immunology, McGill University, Montréal, Canada

³Experimental Medicine, McGill University, Montréal, Canada

⁴CNRS UMR 5236, Université de Bordeaux 2, Bordeaux, France

⁵RNA Group/Groupe ARN, Département de Biochimie, Université de Sherbrooke, Sherbrooke, Québec, Canada

⁶CNRS UMR 5236-UMI/UMII, CPBS - Equipe ''Assemblage et Réplication des Rétrovirus'', Montpellier, France

corresponding author email

from Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts
Montpellier, France. 21-23 September 2009

Retrovirology 2009, 6(Suppl 2):P47doi:10.1186/1742-4690-6-S2-P47


Published:	24 September 2009

First paragraph (this article has no abstract)

RNA-based compounds are promising methods to inactivate viruses. New specific hepatitis delta virus (HDV)-derived ribozymes are natural molecules that can be engineered to specifically target a viral RNA. We have designed specific on-off adapted (SOFA) HDV-ribozymes targeting the regions of the HIV-1 RNA in the Tat and Rev sequences.