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This article is part of the supplement: Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts

Open Access Poster presentation

Inhibition of HIV-1 expression and replication by SOFA-HDV ribozymes against Tat and Rev mRNA sequences

Sébastien Lainé4,1,2*, Robert J Scarborough1,2, Dominique Lévesque5, Ludovic Didierlaurent6, Kaitlin J Soye1,2, Marylène Mougel6, Jean-Pierre Perreault5 and Anne Gatignol3,1,2

  • * Corresponding author: Sébastien Lainé

Author Affiliations

1 Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical Research, McGill University, Montréal, Canada

2 Department of Microbiology and Immunology, McGill University, Montréal, Canada

3 Experimental Medicine, McGill University, Montréal, Canada

4 CNRS UMR 5236, Université de Bordeaux 2, Bordeaux, France

5 RNA Group/Groupe ARN, Département de Biochimie, Université de Sherbrooke, Sherbrooke, Québec, Canada

6 CNRS UMR 5236-UMI/UMII, CPBS - Equipe ''Assemblage et Réplication des Rétrovirus'', Montpellier, France

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Retrovirology 2009, 6(Suppl 2):P47 doi:10.1186/1742-4690-6-S2-P47

Published: 24 September 2009

First paragraph (this article has no abstract)

RNA-based compounds are promising methods to inactivate viruses. New specific hepatitis delta virus (HDV)-derived ribozymes are natural molecules that can be engineered to specifically target a viral RNA. We have designed specific on-off adapted (SOFA) HDV-ribozymes targeting the regions of the HIV-1 RNA in the Tat and Rev sequences.