Retrovirology

official impact factor 5.24

This article is part of the supplement: AIDS Vaccine 2009

Open Access Oral presentation

OA011-04. Striking elevations in systemic and mucosal cytokine and chemokine levels in acute HIV-1 infection

A Stacey1*, P Norris2, O Dibben1, L Qin3, M Cohen4, C Gay4, T Denny5 and P Borrow6

  • * Corresponding author: A Stacey

Author Affiliations

1 Jenner Institute, University of Oxford, Newbury, UK

2 Blood Systems Research Institute, San Francisco, CA, USA

3 SCHARP, Seattle, WA, USA

4 University of North Carolina, Durham, NC, USA

5 Duke University, Durham, USA

6 Jenner Institue, University of Oxford, Newbury, UK

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Retrovirology 2009, 6(Suppl 3):O10 doi:10.1186/1742-4690-6-S3-O10

Published: 22 October 2009

First paragraph (this article has no abstract)

Innate immune responses can be activated rapidly in response to infection and may contribute to control of early viral replication or conversely, mediate immunopathogenic effects. To gain insight into the nature and kinetics of the earliest cytokine responses activated in acute HIV-1 infection (AHI), we analysed changes in systemic and mucosal cytokine/chemokine levels during primary infection.