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This article is part of the supplement: AIDS Vaccine 2009

Open Access Oral presentation

S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects

S Munshaw1*, H Liao1, A Dixon1, X Chen1, A Nagel1, K Derosa1, R Parks1, J Amos1, JF Whitesides1, DJ Marshalls1, Y Yang1, F Gao1, GD Tomaras1, MA Moody1, GH Kelsoe1, TC Shea2, DM Margolis2, M Markowitz2, P Goepfert3, G Shaw3, BF Haynes1 and TB Kepler1

  • * Corresponding author: S Munshaw

Author Affiliations

1 Duke University, Durham, NC, USA

2 University of North Carolina, Chapel Hill, NC, USA

3 University of Alabama, Birmingham, AL, USA

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Retrovirology 2009, 6(Suppl 3):O4 doi:10.1186/1742-4690-6-S3-O4

Published: 22 October 2009

First paragraph (this article has no abstract)

In acute HIV-1 infection (AHI) there are infection-induced polyclonal shifts in blood and bone marrow B-cell subsets from naïve to memory cells and plasmablasts/plasma cells (PCs) coupled with decreased numbers of naive B cells. To study the initial antibody response to HIV, we have used recombinant technology to create a database of PC antibody sequences derived from 3 early stage AHI subjects.